QR Code
Laura Sanchez-Sandoval, Ana; Carlos Gomora, Juan (2019)

CONTRIBUTION OF VOLTAGE-GATED SODIUM CHANNEL BETA-SUBUNITS TO CERVICAL CANCER CELLS METASTATIC BEHAVIOR

Cancer Cell Int. 19():
full text

Voltage-gated sodium (Na) channels are heteromeric proteins consisting of a single pore forming α-subunit associated with one or two auxiliary β-subunits. These channels are classically known for being responsible of action potential generation and propagation in excitable cells; but lately they have been reported as widely expressed and regulated in several human cancer types. We have previously demonstrated the overexpression of Na1.6 channel in cervical cancer (CeCa) biopsies and primary cultures, and its contribution to cell migration and invasiveness. Here, we investigated the expression of Na channels β-subunits (Naβs) in the CeCa cell lines HeLa, SiHa and CaSki, and determined their contribution to cell proliferation, migration and invasiveness.