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Publicaciones Jesús Adolfo García-Sáinz
  • Solís, K. H., Romero-Ávila, M. T., Alcántara-Hernández, R., & García-Sáinz, J. A. (2025). The many facets of biased signaling: Mechanisms and possible therapeutic implications. Pharmacology & Therapeutics, 272, 108877. https://doi.org/10.1016/j.pharmthera.2025.108877
  • Solís, K. H., Romero-Ávila, M. T., Rincón-Heredia, R., & García-Sáinz, J. A. (2024). Lysophosphatidic Acid Receptor 3 (LPA3): Signaling and Phosphorylation Sites. International Journal of Molecular Sciences, 25(12), 6491. https://doi.org/10.3390/ijms25126491
  • Solís, K. H., Romero-Ávila, M. T., Rincón-Heredia, R., & García-Sáinz, J. A. (2024). LPA3 Receptor Phosphorylation Sites: Roles in Signaling and Internalization. International Journal of Molecular Sciences, 25(10), 5508. https://doi.org/10.3390/ijms25105508
  • Hernández-Espinosa, D. A., Alcántara-Hernández, R., Solís, K. H., & García-Sáinz, J. A. (2023). Roles of the ?1B-Adrenergic Receptor Phosphorylation Domains in Signaling and Internalization. International Journal of Molecular Sciences, 24(23), 16963. https://doi.org/10.3390/ijms242316963
  • Martínez-Morales, J. C., González-Ruiz, K. D., Romero-Ávila, M. T., Rincón-Heredia, R., Reyes-Cruz, G., & García-Sáinz, J. A. (2023). Lysophosphatidic acid receptor LPA1 trafficking and interaction with Rab proteins, as evidenced by Förster resonance energy transfer. Molecular and Cellular Endocrinology, 570, 111930. https://doi.org/10.1016/j.mce.2023.111930
  • Alcantara-Hernandez, Rocio; Hernandez-Espinosa, David A; Medina, Luz del C; Garcia-Sainz, Jesus A (2022). G protein-coupled receptors as therapeutic target GACETA MEDICA DE MEXICO 158 (2) :101-107
  • Guzman-Silva, Alejandro; Carlos Martinez-Morales, Juan; del Carmen Medina, Luz; Teresa Romero-Avila, M; Villegas-Comonfort, Socrates; Helivier Solis, Karina; J Adolfo Garcia-Sainz (2022). Mutation of putative phosphorylation sites in the free fatty acid receptor 1: Effects on signaling, receptor phosphorylation, and internalization Mol Cell Endocrinol 545
  • Martínez-Morales JC; Solís KH; Romero-Ávila MT; Reyes-Cruz G; García-Sáinz JA (2022). Cell Trafficking and Function of G Protein-coupled Receptors ARCH MED RES 53 (5) :451-460
  • Martínez-Morales JC; Romero-Ávila MT; Reyes-Cruz G; García-Sáinz JA (2022). Roles of Receptor Phosphorylation and Rab Proteins in G Protein-Coupled Receptor Function and Trafficking 101 (3) :144-153
  • Solís, K. H., Romero-Ávila, M. T., Guzmán-Silva, A., & García-Sáinz, J. A. (2021). The LPA3 Receptor: Regulation and Activation of Signaling Pathways. International Journal of Molecular Sciences, 22(13), 6704. doi:10.3390/ijms22136704
  • Flores-Espinoza, E., Meizoso-Huesca, A., Villegas-Comonfort, S., Reyes-Cruz, G., & García-Sáinz, J. A. (2020). Effect of docosahexaenoic acid, phorbol myristate acetate, and insulin on the interaction of the FFA4 (short isoform) receptor with Rab proteins. European Journal of Pharmacology, 889, 173595. doi:10.1016/j.ejphar.2020.173595
  • de-los-Santos-Cocotle, G., Martínez-Morales, J. C., Romero-Ávila, M. T., Reyes-Cruz, G., & García-Sáinz, J. A. (2020). Effects of agonists and phorbol esters on ?1A-adrenergic receptor-Rab protein interactions. European Journal of Pharmacology, 885, 173423. doi:10.1016/j.ejphar.2020.173423
  • Flores-Hernández, E., Velázquez, D. M., Castañeda-Patlán, M. C., Fuentes-García, G., Fonseca-Camarillo, G., Yamamoto-Furusho, J. K., ? Robles-Flores, M. (2020). Canonical and non-canonical Wnt signaling are simultaneously activated by Wnts in colon cancer cells. Cellular Signalling, 72, 109636. doi:10.1016/j.cellsig.2020.109636
  • Hernández-Espinosa, D. A., Reyes-Cruz, G., & García-Sáinz, J. A. (2020). Roles of the G protein-coupled receptor kinase 2 and Rab5 in ?1B-adrenergic receptor function and internalization. European Journal of Pharmacology, 867, 172846. doi:10.1016/j.ejphar.2019.172846
  • Alcántara-Hernández, R., Carmona-Rosas, G., Hernández-Espinosa, D. A., & García-Sáinz, J. A. (2020). Glycogen Synthase Kinase-3 modulates ?1A-adrenergic receptor action and regulation. European Journal of Cell Biology, 99(2-3), 151072. doi:10.1016/j.ejcb.2020.151072
  • Nascimento-Viana, J. B., Alcántara-Hernández, R., Oliveira-Barros, E., Castello Branco, L. A., Feijó, P. R., Soares Romeiro, L. A., ? Silva, C. L. M. (2019). The ?1-adrenoceptor-mediated human hyperplastic prostate cells proliferation is impaired by EGF receptor inhibition. Life Sciences, 239, 117048. doi:10.1016/j.lfs.2019.117048
  • Villegas-Comonfort, S., Guzmán-Silva, A., Romero-Ávila, M. T., Takei, Y., Tsujimoto, G., Hirasawa, A., & García-Sáinz, J. A. (2019). Receptor tyrosine kinase activation induces free fatty acid 4 receptor phosphorylation, ?-arrestin interaction, and internalization. European Journal of Pharmacology, 855, 267?275. doi:10.1016/j.ejphar.2019.05.018
  • Carmona-Rosas, G., Hernández-Espinosa, D. A., Alcántara-Hernández, R., Alfonzo-Méndez, M. A., & García-Sainz, J. A. (2019). Distinct phosphorylation sites/clusters in the carboxyl terminus regulate ?1D-adrenergic receptor subcellular localization and signaling. Cellular Signalling, 53, 374?389. doi:10.1016/j.cellsig.2018.11.003
  • Hernández-Espinosa, D. A., Carmona-Rosas, G., Alfonzo-Méndez, M. A., Alcántara-Hernández, R., & García-Sáinz, J. A. (2019). Sites phosphorylated in human ?1B-adrenoceptors in response to noradrenaline and phorbol myristate acetate. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1866(10), 1509?1519. doi:10.1016/j.bbamcr.2019.07.006
  • Akinaga, J., García-Sáinz, J. A., & Pupo, A. S. (2019). Updates in the Function and Regulation of ?1 -Adrenoceptors. British Journal of Pharmacology. doi:10.1111/bph.14617
  • Martínez-Morales, J. C., Romero-Ávila, M. T., Reyes-Cruz, G., & García-Sáinz, J. A. (2018). S1P1 receptor phosphorylation, internalization, and interaction with Rab proteins: effects of sphingosine 1-phosphate, FTY720-P, phorbol esters, and paroxetine. Bioscience Reports, 38(6). doi:10.1042/bsr20181612
  • Meizoso?Huesca, A., Villegas?Comonfort, S., Romero?Ávila, M. T., & García?Sáinz, J. A. (2018). Free fatty acid receptor 4 agonists induce lysophosphatidic acid receptor 1 ( LPA 1 ) desensitization independent of LPA 1 internalization and heterodimerization. FEBS Letters, 592(15), 2612?2623. doi:10.1002/1873-3468.13179
  • Alfonzo-Méndez, M. A., Carmona-Rosas, G., Hernández-Espinosa, D. A., Romero-Ávila, M. T., & García-Sáinz, J. A. (2018). Different phosphorylation patterns regulate ?1D-adrenoceptor signaling and desensitization. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1865(6), 842?854. doi:10.1016/j.bbamcr.2018.03.006
  • Alcántara-Hernández, R., Hernández-Méndez, A., Romero-Ávila, M. T., Alfonzo-Méndez, M. A., Pupo, A. S., & García-Sáinz, J. A. (2017). Noradrenaline, oxymetazoline and phorbol myristate acetate induce distinct functional actions and phosphorylation patterns of ?1A-adrenergic receptors. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1864(12), 2378?2388. doi:10.1016/j.bbamcr.2017.09.002
  • Carmona-Rosas, G., Alfonzo-Méndez, M. A., Hernández-Espinosa, D. A., Romero-Ávila, M. T., & García-Sáinz, J. A. (2017). A549 cells as a model to study endogenous LPA 1 receptor signaling and regulation. European Journal of Pharmacology, 815, 258?265. doi:10.1016/j.ejphar.2017.09.013
  • Villegas-Comonfort, S., Takei, Y., Tsujimoto, G., Hirasawa, A., & García-Sáinz, J. A. (2017). Effects of arachidonic acid on FFA4 receptor: Signaling, phosphorylation and internalization. Prostaglandins, Leukotrienes and Essential Fatty Acids, 117, 1?10. doi:10.1016/j.plefa.2017.01.013
  • Alfonzo-Méndez, M. A., Hernández-Espinosa, D. A., Carmona-Rosas, G., Romero-Ávila, M. T., Reyes-Cruz, G., & García-Sáinz, J. A. (2017). Protein Kinase C Activation Promotes ?1B-Adrenoceptor Internalization and Late Endosome Trafficking through Rab9 Interaction. Role in Heterologous Desensitization. Molecular Pharmacology, 91(4), 296?306. doi:10.1124/mol.116.106583
  • Alfonzo-Méndez, M., Alcántara-Hernández, R., & García-Sáinz, J. (2016). Novel Structural Approaches to Study GPCR Regulation. International Journal of Molecular Sciences, 18(1), 27. doi:10.3390/ijms18010027
  • Silva, Claudia Lucia M; Nascimento-Viana, Jessica B; Alcantara-Hernandez, Rocio; Adolfo Garcia-Sainz, J; Noel, Francois (2016). EGF Receptor Transactivation by alpha(1)-Adrenoceptors on Prostatic Hyperplastic Cells FASEB JOURNAL 30
  • Alfonzo-Mendez, Marco A; Castillo-Badillo, Jean A; Teresa Romero-Avila, M; Adolfo Garcia-Sainz, J (2016). Alpha-1D-Adrenoceptors Lacking Their Carboxyl Terminus Inhibit The MAPK/ERK Pathway in Rat-1 Fibroblasts FASEB JOURNAL 30
  • Pupo, A. S., & García-Sáinz, J. A. (2016). A Latin American Perspective on G Protein?Coupled Receptors. Molecular Pharmacology, 90(5), 570?572. doi:10.1124/mol.116.106062
  • Alfonzo-Méndez, M. A., Castillo-Badillo, J. A., Romero-Ávila, M. T., Rivera, R., Chun, J., & García-Sáinz, J. A. (2016). Carboxyl terminus-truncated ?1D-adrenoceptors inhibit the ERK pathway. Naunyn-Schmiedeberg?s Archives of Pharmacology, 389(8), 911?920. doi:10.1007/s00210-016-1254-2
  • Nascimento-Viana, J. B., Carvalho, A. R., Nasciutti, L. E., Alcantara-Hernandez, R., Chagas-Silva, F., Souza, P. A. R., ? Silva, C. L. M. (2015). New Multi-target Antagonists of  1A-,  1D-Adrenoceptors and 5-HT1A Receptors Reduce Human Hyperplastic Prostate Cell Growth and the Increase of Intraurethral Pressure. Journal of Pharmacology and Experimental Therapeutics, 356(1), 212?222. doi:10.1124/jpet.115.227066


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