Down-Regulation–Resistant STAT4 Risk Haplotype Contributes to Lupus Nephritis Through CD4+ T Cell Interferon-γ Production
Madera-Salcedo IK; Ramirez-Sanchez AL; Rodriguez-Rodriguez N; Garcia-Quintero R; Rubio RM; Morales-Montes de Oca G; Dvalos E; Cuervo R; Furuzawa-Carballeda J; Alcocer-Varela J; Gomez-Martn D; Gonzalez-Yez M; de la Cruz A; Albarrn-Godinez A; Suarez-Rojas G; Romero-Diaz J; Uribe-Uribe NO; Alarcon-Riquelme M; Furlan-Magaril M; Mejia-Vilet JM; Crispin JC; Rosetti F (2023). Down-Regulation–Resistant STAT4 Risk Haplotype Contributes to Lupus Nephritis Through CD4+ T Cell Interferon-γ Production Arthritis Rheumatol 75 :961-972
Variants in STAT4 are associated with systemic lupus erythematosus (SLE) and other autoimmune diseases. We undertook this study to investigate how disease-associated variants affect STAT4 expression, in particular in CD4+ T cells where STAT4 plays an essential role.