Histamine impairs midbrain dopaminergic development in vivo by activating histamine type 1 receptors
Escobedo-Avila, I., Vargas-Romero, F., Molina-Hernández, A., López-González, R., Cortés, D., De Carlos, J. A., & Velasco, I. (2014). Histamine impairs midbrain dopaminergic development in vivo by activating histamine type 1 receptors. Molecular Brain, 7(1). doi:10.1186/s13041-014-0058-x
ABSTRACT
Histamine (HA) regulates the sleep-wake cycle, synaptic plasticity and memory in adult mammals. Dopaminergic specification in the embryonic ventral midbrain (VM) coincides with increased HA brain levels. To study the effect of HA receptor stimulation on dopamine neuron generation, we administered HA to dopamine progenitors, both in vitro and in vivo.