Chordacentrum mineralization is delayed in zebrafish betaglycan-null mutants
MolinaâVilla, T., RamÃrezâVidal, L., Mendoza, V., EscalanteâAlcalde, D., & LópezâCasillas, F. (2021). Chordacentrum mineralization is delayed in zebrafish betaglycanânull mutants. Developmental Dynamics. doi:10.1002/dvdy.393
ABSTRACT
The Transforming Growth Factor β (TGFβ) family is a group of related proteins that signal through a type I and type II receptors. Betaglycan, also known as the type III receptor (Tgfbr3), is a coreceptor for various ligands of the TGFβ family that participates in heart, liver and kidney development as revealed by the tgfbr3-null mouse, as well as in angiogenesis as revealed by Tgfbr3 downregulation in morphant zebrafish.