Actin-cytoskeleton polymerization differentially controls the stability of Ski and SnoN co-repressors in normal but not in transformed hepatocytes
Caligaris, C., Vázquez-Victorio, G., Sosa-Garrocho, M., Ríos-López, D. G., Marín-Hernández, A., & Macías-Silva, M. (2015). Actin-cytoskeleton polymerization differentially controls the stability of Ski and SnoN co-repressors in normal but not in transformed hepatocytes. Biochimica et Biophysica Acta (BBA) - General Subjects, 1850(9), 1832–1841. doi:10.1016/j.bbagen.2015.05.012
ABSTRACT
Ski and SnoN proteins function as transcriptional co-repressors in the TGF-β pathway. They regulate cell proliferation and differentiation, and their aberrant expression results in altered TGF-β signalling, malignant transformation, and alterations in cell proliferation.