Proinflammatory cytokine MIF plays a role in the pathogenesis of type-2 diabetes mellitus, but does not affect hepatic mitochondrial function
Rodriguez-Sosa, M., Cabellos-Avelar, T., Sanchez-Zamora, Y., Juárez-Avelar, I., García-Reyes, E., Lira-León, A., ? Gutiérrez-Cirlos, E. B. (2017). Proinflammatory cytokine MIF plays a role in the pathogenesis of type-2 diabetes mellitus, but does not affect hepatic mitochondrial function. Cytokine, 99, 214?224. doi:10.1016/j.cyto.2017.07.012
ABSTRACT
Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine that plays an important role in the pathogenesis of type 2 diabetes mellitus (T2DM). Although the effect of high glucose on liver function has been described, the role of MIF in hepatic mitochondrial function during T2DM has not been studied.