The CD4+ T cell regulatory network mediates inflammatory responses during acute hyperinsulinemia: A simulation study
Martinez-Sanchez, M. E., Hiriart, M., & Alvarez-Buylla, E. R. (2017). The CD4+ T cell regulatory network mediates inflammatory responses during acute hyperinsulinemia: a simulation study. BMC Systems Biology, 11(1). doi:10.1186/s12918-017-0436-y
ABSTRACT
Obesity is frequently linked to insulin resistance, high insulin levels, chronic inflammation, and alterations in the behaviour of CD4+ T cells. Despite the biomedical importance of this condition, the system-level mechanisms that alter CD4+ T cell differentiation and plasticity are not well understood.