Putrescine treatment reverses α-tocopherol-induced desynchronization of polyamine and retinoid metabolism during rat liver regeneration
Sánchez-Sevilla, L., Mendieta-Condado, E., & Hernández-Muñoz, R. (2016). Putrescine treatment reverses ?-tocopherol-induced desynchronization of polyamine and retinoid metabolism during rat liver regeneration. Journal of Translational Medicine, 14(1). doi:10.1186/s12967-016-1062-y
The pre-treatment with α-tocopherol inhibits progression of rat liver proliferation induced by partial hepatectomy (PH), by decreasing and/or desynchronizing cyclin D1 expression and activation into the nucleus, activation and nuclear translocation of STAT-1 and -3 proteins and altering retinoid metabolism. Interactions between retinoic acid and polyamines have been reported in the PH-induced rat liver regeneration. Therefore, we evaluated the effect of low dosage of α-tocopherol on PH-induced changes in polyamine metabolism.