Long-term production of BDNF and NT-3 induced by A91-immunization after spinal cord injury
Martiñón, S., García-Vences, E., Toscano-Tejeida, D., Flores-Romero, A., Rodriguez-Barrera, R., Ferrusquia, M., ? Ibarra, A. (2016). Long-term production of BDNF and NT-3 induced by A91-immunization after spinal cord injury. BMC Neuroscience, 17(1). doi:10.1186/s12868-016-0267-6
ABSTRACT
After spinal cord (SC)-injury, a non-modulated immune response contributes to the damage of neural tissue. Protective autoimmunity (PA) is a T cell mediated, neuroprotective response induced after SC-injury. Immunization with neural-derived peptides (INDP), such as A91, has shown to promote-in vitro-the production of neurotrophic factors. However, the production of these molecules has not been studied at the site of injury.