Role of NADPH oxidases in inducing a selective increase of oxidant stress and cyclin D1 and checkpoint 1 over-expression during progression to human gastric adenocarcinoma
Montalvo-Javé, E. E., Olguín-Martínez, M., Hernández-Espinosa, D. R., Sánchez-Sevilla, L., Mendieta-Condado, E., Contreras-Zentella, M. L., ? Hernández-Muñoz, R. (2016). Role of NADPH oxidases in inducing a selective increase of oxidant stress and cyclin D1 and checkpoint 1 over-expression during progression to human gastric adenocarcinoma. European Journal of Cancer, 57, 50?57. doi:10.1016/j.ejca.2015.11.027
ABSTRACT
Gastric cancer is one of the main causes of global mortality. Here, reactive oxygen species (ROS) could largely contribute to gastric carcinogenesis. Hence, the present work was aimed to assess the role of ROS, oxidant status, NADPH oxidases (NOXs) expression, during human gastric adenocarcinoma.