Epigenetic silencing of miR-181c by DNA methylation in glioblastoma cell lines
Ayala-Ortega, E., Arzate-Mejía, R., Pérez-Molina, R., González-Buendía, E., Meier, K., Guerrero, G., & Recillas-Targa, F. (2016). Epigenetic silencing of miR-181c by DNA methylation in glioblastoma cell lines. BMC Cancer, 16(1). doi:10.1186/s12885-016-2273-6
ABSTRACT
Post-transcriptional regulation by microRNAs is recognized as one of the major pathways for the control of cellular homeostasis. Less well understood is the transcriptional and epigenetic regulation of genes encoding microRNAs. In the present study we addressed the epigenetic regulation of the miR-181c in normal and malignant brain cells.