Luis Vaca Domínguez

Intereses de Investigación

1) TRPC channel modulation and function
2) Signal transduction and calcium
3) Technology development for the generation of novel vaccines and for super resolution imaging.

Trayectoria Profesional

Investigador Titular C

Posdoctorados y Estancias

Baylor College of Medicine, Houston, Texas. USA, (1987-1992)
Technische Universitaet Munchen, Munich, Germany, (1999-2001)

Formación Académica

Médico Cirujano, UAM, México (1980-1985)

Investigación Biomédica, UNAM, México (1986-1988)

Doctor en Ciencias Biomédicas, UNAM, México (1993-1995)

Premios y Distinciones

Premio CANIFARMA en Tecnología., (2017)
Premio CANIFARMA en Tecnología., (2016)
Premio Roche Dr. Jorge Rosenkranz en el área Biotecnológica, (2016)
Premio CANIFARMA en Tecnología, (2010)
Premio Silanes al mejor articulo de investigación básica 2004, (2004)
Premio Miguel Alemán en Investigación en Salud 2001, (2001)
Medalla Gabino Barreda al Mérito Universitario, (1997)
The Third World Academy of Sciences Research Grant, (1997)
Training Grant from the National Institutes of Health (NIH). , (1995)
R29 (First award) from the National Institutes of Health (NIH). , (1995)

Ligas de Interés

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Líneas de Investigación

Imaging-based point-of-care diagnostics: We are developing new technologies which facilitate ambulatory point-of-care (POC) diagnostics based on imaging and nucleic acids identification. We have developed and patented a novel form of illumination based on total internal reflection microscopy (TIRFM) which can be used to scan nucleic acid, protein and other bioanalytes microarrays. Our self-contained imaging systems are portable and easy to use for the identification of single nucleotide polymorphisms (SNIPs) and DNA7RNA signatures of pathogens with medical interest.

Self aggregating peptides as vaccine vehicles: We are synthesizing self-aggregating peptides (SAPs) capable of assembling nanoparticles of different geometries and sizes. These self-aggregating peptides function as vehicles and adyuvants in vaccines. They stimulate a robust immune response against the fused epitope. Because SAPs produce nanoparticles, they are very easy to precipitate by low speed centrifugation, reducing the cost of vaccine purification and preparation.

Store-operated calcium entry: We are interested in studying the molecular mechanisms underlying calcium influx upon depletion of the Endoplasmic Reticulum. We identified for the first time the TRPC family of channels as the molecular entities responsible for Store-operated calcium entry (SOCE) in 1992. Currently we are identifying novel members from the macromolecular complex involved in SOCE, we have named this complex SOCIC (Store-operated calcium influx complex). We have shown the role of microtubule protein such as EB1 and APC in controlling SOCE ans SOCIC assembly. New members from the SOCIC complex are identified continuously.

Integrantes del Laboratorio

Alicia Sampieri García

Estudiantes