Dimitris Georgellis

Intereses de Investigación

El principal interés de nuestro laboratorio se enfoca en los mecanismos mediante los cuales las células se comunican con su ambiente y la forma en que esa información es utilizada para controlar la expresión génica. Los temas predominantes de nuestra investigación son:
Estructura y función de las proteínas involucradas en la transducción de señales en bacterias.
Control de la expresión génica en bacterias en respuesta a estímulos extra celulares.

Trayectoria Profesional

Investigador Titular C

Posdoctorados y Estancias

Depto de Microbiología y Genética Molecular, Harvard Medical School, Boston / USA, (1996-2001)
Instituto de Microbiología Genética, Universidad de Vienna, Vienna / Austria, (1995-1996)

Formación Académica

Ph.D. (Molecular Biology), Instituto Karolinska, Stockholm, Sweden (1991-1995)

Líneas de Investigación

Two-component signal transdution: The ability to respond to a vast array of environmental signals is vital for the growth and survival of microorganisms. The sensing and processing of these signals are carried out by molecular circuits within the cell which detect, amplify and integrate these signals into a specific response. In prokaryotes, these molecular circuits are typically organized by protein pairs, "sensory kinase" proteins and "response regulator" proteins, that belong to the large family of two-component systems (TCS). We are now studying two analogous signal transduction pathways: i) the ArcB/ArcA TCS which plays a key role in regulating energy metabolism at the level of transcription, and ii) the BarA/UvrY TCS which is involved in virulence. Our research is directed toward understanding the molecular mechanisms of signal transduction in these systems as well as their scope of control.

Investigador Adjunto

Adrián Fernando Alvarez

Integrantes del Laboratorio

Claudia Rodríguez Rangel

Estudiantes