Currently we are involved in several projects aiming to identify:

1.How the basal ganglia (BG) sub-circuits encodes action chunks (see publications 2014).

2.How the BG sub-circuits activity contributes to contraversive movements (see publications 2014).

3.How the BG sub-circuits activity contributes to the initiation/performance of action (see publications 2016).

4. The dopaminergic activity on action initiation/performance (with PhD student Joaquim Silva in Dr Costa lab).

  1. 5.The striatal projections to the midbrain (with PhD student Sevinc Mutlu in Dr Costa lab).

  1. 6.The thalamic inputs to the BG and their contributions on action initiation [with Edgar (see people)].

  1. 7.The cortical inputs to the BG and their contributions on actions transitions  [with Asai (see people)].

  1. 8.The BG pathways contributions on action transitions  [with Kathia (see people)].

  1. 9.The cholinergic contribution to goal directed actions [with Hector (see people)].

  1. 10.Setting up calcium imaging  [with Iván (see people)].

  1. 11.Dopamine/glutamate correlease on prefrontal cortices, its contribution to behavior  [with José Luís (see people)].

  1. 12.The BG pathways contributions on operant behaviors  [with Nisa (see people)].

  1. 13.Setting up a head fix tasks [with Argelia (see people)].

Lab Research

In the lab we study how the activity of the brain shapes the initiation, performance and switch between motor actions. Particularly we center our attention in how the activity in the cortico-basal ganglia-thalamic loops contributes in the control of motor actions in normal as in neuropathological conditions.

To perform our research we measure the activity of particular neuronal sub-circuits of the brain using state of the art techniques (we use trangenic mice capable of expressing proteins of interest to perform opto-physiological, calcium imaging and electrophysiological recordings). Then based on these recordings we execute neuronal activity manipulations (using optogenetics) in specific sub-circuits of the brain in freely moving animals performing operant behaviors. Our ultimate goal is to dissect the general contributions that the different sub-circuits of the cortico–basal ganglia–thalamic loops exert to support normal and pathological behaviors.

Made on a Mac

Instituto de Fisiología Celular, UNAM.

Circuito Exterior s/n, Ciudad Universitaria, Coyoacán, Distrito Federal, México.

Zip code: 04510

Phone (+52) 55 56225585