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Instituto de Fisiologia Celular UNAM
Tamara Luti Rosenbaum Emir
Neural Development and Physiology
trosenba@ifc.unam.mx
Tel: (52) (55) 56225624
About:
B.S. Facultad de Ciencias, UNAM, 1992; PhD: Instituto de Fisiologúa Celular, UNAM, 1998. Posdoctoral training: State University of New York at Stony Brook (1999-2000); University of Washington at Seattle (2000-2004).
Awardee of the prize for best "Young Researcher in the area of Natural Sciences" of UNAM (2008).
Awardee of the Mexican Academy of Sciences for best "Young Researcher in the area of Natural Sciences" (2011).  
 


Research Interests:
Transient receptor potential (TRP) channels were first described in Drosophila, where photoreceptors carrying trp gene mutations exhibited a transient voltage response to continuous light. Since that time the TRP channel family has grown to include at least 20 members. TRP channels exhibit a wide variety of functions: invertebrate phototransduction; responses to painful stimuli and to moderate temperature changes; regulation of intracellular calcium stores; receptorúmediated excitation; and modulation of the cell cycle. Despite the clear physiological importance of TRP channels, little is known about what regulates their function or about their structure. One type of TRP channel, TRPV1, is a polymodal receptor that integrates a number of painful stimuli. These stimuli include: noxious heat, with a threshold of approximately 42úC; extracellular acidification, with a pKa of about 5.3; anandamide and other arachidonic acid metabolites; and capsaicin, a pungent extract from plants in the Capsicum family. My lab studies the molecular mechanisms of activation and regulation of TRPV1 and TRPM8 channels which function not only as intrinsic sensors of the cellular environment but also in the whole organism. We use a combination of electrophysiological, molecular biology and biochemical techniques to study their structural and functional properties. PLEASE GO TO Rosenbaum Lab Website
Projects:
MOLECULAR BASIS OF TRP CHANNEL ACTIVATION
ACTIVATION OF TRP CHANNELS BY TEMPERATURE
Selected Articles
Ca2+/calmodulin modulates TRPV1 activation by capsaicin (2004)
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Distinction among neuronal subtypes of voltage-activated sodium channels by mu-conotoxin PIIIA (2000)
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Pancreatic beta cells synthesize and secrete nerve growth factor (1998)
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View selected articles: Tamara Luti Rosenbaum Emir
All Articles:
Tamara Luti Rosenbaum Emir
Lysophosphatidic acid directly activates TRPV1 through a C-terminal binding site (2012)
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Identification of a Binding Motif in the S5 Helix That Confers Cholesterol Sensitivity to the TRPV1 Ion Channel (2011)
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Uncoupling Charge Movement from Channel Opening in Voltage-gated Potassium Channels by Ruthenium Complexes (2011)
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View more articles: Tamara Luti Rosenbaum Emir
Next Seminars
Webcast transmission  
Fridays at noon
"Transmembrane Signaling by Bacterial Chemoreceptors: A Dynamic Story?".
Dr. John S. Parkinson, University of Utah, USA. | viernes 18 de Mayo, 2012
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"Microscopía de una nueva nanoRNP".
Dr. Luis Felipe Jiménez, Facultad de Ciencias, UNAM. | viernes 25 de Mayo, 2012
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"La Multicobre Oxidasa de Thermus thermophilus por medio de cristalografia de rayos X: el efecto de la dosis acumulada".
Dr. Enrique Rudino Pineira, Instituto de Biotecnología, UNAM. | viernes 1 de Junio, 2012
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UNAM
 Instituto de Fisiología Celular | Universidad Nacional Autónoma de México
Circuito Exterior S/N Ciudad Universitaria, Coyoacán, 04510 México D.F.
Fax (52) (55) 5616-2282 | www@ifc.unam.mx