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Melo, Zesergio; Castillo, Ximena; Moreno-Carranza, Bibiana; Ledesma-Colunga, Maria G; Arnold, Edith; Lopez-Casillas, Fernando; Ruiz-Herrera, Xarubet; Clapp, Carmen; Martinez de la Escalera, Gonzalo (2019)

VASOINHIBIN SUPPRESSES NERVE GROWTH FACTOR-INDUCED DIFFERENTIATION AND SURVIVAL OF PC12 PHEOCHROMOCYTOMA CELLS

Neuroendocrinology 109(2):152-164
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Vasoinhibin, a protein derived from prolactin, regulates various vascular functions including endothelial cell survival. Of note, vasoinhibin is present in the central nervous system, where it triggers neuroendocrine and behavioral responses to stress. Moreover, vasoinhibin compromises nerve growth factor (NGF)-induced neurite outgrowth in primary sensory neurons of the peripheral nervous system. Nonetheless, information on the functions of vasoinhibin in developing neurons remains limited. The present study explored whether vasoinhibin affects the neurotrophic actions of NGF by measuring the cell differentiation and survival of PC12 pheochromocytoma cells.