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Jara-Oseguera A; Rosenbaum T (2012)

TRPV1 IN CELL SIGNALING: MOLECULAR MECHANISMS OF FUNCTION AND MODULATION

Mechanically Gated Channels and their Regulation ():69-102
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© Springer Science+Business Media Dordrecht 2012. The TRPV 1 channel is a polymodal receptor that has been implicated in several physiological and pathological processes including painful stimuli detection, inflammation, hyperalgesia and, recently, mechanotransduction. This channel can be directly activated by acidic pH, bioactive lipids, cysteine-modifying molecules, extracellular cations, voltage, elevated temperatures and several exogenous molecules such as capsaicin and toxins from animals. Moreover, its function can be modulated by the action of protein kinases, lipids, the cytoskeleton, second messengers and many proteins involved in signaling processes. Hence, the TRPV1 channel sits in the middle of the cell’s intracellular signaling network and its communication with the external environment. Understanding the molecular mechanisms that govern TRPV1 channel function will certainly allow us to obtain a deeper insight into the physiology of cells and organisms. Here we review the latest discoveries pertaining the mechanisms and signaling processes that affect TRPV1 activity.