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Georgellis, D; Chavez, RG; Alvarez, AF; Romeo, T (2010)

THE PHYSIOLOGICAL STIMULUS FOR THE BARA SENSOR KINASE

J BACTERIOL 192(7):2009-2012
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The two-component signal transduction system (TCS) BarA/UvrY activates transcription of CsrB and CsrC noncoding RNAs, which act by sequestering the RNA-binding global regulatory protein CsrA. Here, we show that the metabolic end products formate and acetate provide a physiological stimulus for this TCS and thus link posttranscriptional regulation by the Csr system to the metabolic state of the cell.