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Georgellis, D; Barba-Ostria, C; Lledias, F (2011)

THE NEUROSPORA CRASSA DCC-1 PROTEIN, A PUTATIVE HISTIDINE KINASE, IS REQUIRED FOR NORMAL SEXUAL AND ASEXUAL DEVELOPMENT AND CAROTENOGENESIS

EUKARYOT CELL 10(12):1733-1739
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Two-component signaling pathways based on phosphoryl group transfer between histidine kinase and response regulator proteins regulate environmental responses in bacteria, archaea, plants, slime molds, and fungi. Here we characterize a mutant form of DCC-1, a putative histidine kinase encoded by the NCU00939 gene of the filamentous fungus Neurospora crassa. We show that this protein participates in the regulation of processes such as conidiation, perithecial development, and, to a certain degree, carotenogenesis. Furthermore, DCC-1 is suggested to exert its effect by promoting cyclic AMP production, thereby placing this protein within the context of a signaling pathway.