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Gonzalez-Pedrajo, B; Minamino, T; Kihara, M; Namba, K; Macnab, RM (2003)

THE ATPASE FLII CAN INTERACT WITH THE TYPE III FLAGELLAR PROTEIN EXPORT APPARATUS IN THE ABSENCE OF ITS REGULATOR, FLIH

J BACTERIOL 185(13):3983-3988
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Salmonella FliI is the ATPase that drives flagellar protein export. It normally exists as a complex together with the regulatory protein FliH. A fliH null mutant was slightly motile, with overproduction of Fill resulting in substantial improvement of its motility. Mutations in the cytoplasmic domains of FlhA and FlhB, which are integral membrane components of the type III flagellar export apparatus, also resulted in substantially improved motility, even at normal FliI levels. Thus, FliH, though undoubtedly important, is not essential.