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Ortega-Francisco S; de la Fuente-Granada M; Alvarez Salazar E; Bolaños-Castro L; Fonseca-Camarillo G; Olguin-Alor R; Alemán-Muench G; López-Casillas F; Raman C; García-Zepeda E; Soldevila G (2017)

TβRIII IS INDUCED BY TCR SIGNALING AND DOWNREGULATED IN FOXP3+REGULATORY T CELLS

BIOCHEM BIOPH RES CO 494(1-2):82-87
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© 2017 TGF-β type III receptor (TβRIII) is a co-receptor for TGFβ family members required for high-affinity binding of these ligands to their receptors, potentiating their cellular functions. TGF-βs, Bone Morphogenetic Proteins (BMP2/4) and Inhibins/Activins regulate different checkpoints during T cell differentiation. We have previously reported that TβRIII modulates T cell development by protecting developing thymocytes from apoptosis, however the role of this co-receptor in peripheral lymphocytes still remains elusive. Here we describe a detailed characterization of TβRIII expression in murine and human lymphocyte subpopulations demonstrating that this co-receptor is significantly expressed in T but not B lymphocytes and among them, preferentially expressed on naïve and central memory T cells. TβRIII was upregulated after TCR stimulation, in parallel to other early activation markers. In contrast, natural and induced Tregs downregulated TβRIII in association with FoxP3 upregulation. Finally, anti-TβRIII blocking experiments demonstrated that TβRIII promotes TGFβ-dependent iTreg conversion in vitro, and suggest that this co-receptor may be involved in modulating peripheral T cell tolerance and could be considered as a potential target to boost T cell immune responses.