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Sanchez-Sevilla, Lourdes; Mendieta-Condado, Edgar; Hernandez-Munoz, Rolando (2016)

PUTRESCINE TREATMENT REVERSES ALPHA-TOCOPHEROL-INDUCED DESYNCHRONIZATION OF POLYAMINE AND RETINOID METABOLISM DURING RAT LIVER REGENERATION

J Transl Med 14():
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The pre-treatment with α-tocopherol inhibits progression of rat liver proliferation induced by partial hepatectomy (PH), by decreasing and/or desynchronizing cyclin D1 expression and activation into the nucleus, activation and nuclear translocation of STAT-1 and -3 proteins and altering retinoid metabolism. Interactions between retinoic acid and polyamines have been reported in the PH-induced rat liver regeneration. Therefore, we evaluated the effect of low dosage of α-tocopherol on PH-induced changes in polyamine metabolism.