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Hernandez-Plata, Everardo; Claudia Velazquez-Wong, Ana; Jimenez-Ramirez, Carmina; Fernandez-Ramirez, Fernando; Maria Galicia-Sanchez, Luz; Antonio Flores-Garcia, Cesar; Manuel Hernandez-Hernandez, Jose; Rosas-Vargas, Haydee; Carlos Huicochea-Montiel, Juan; Espinosa-Poblano, Eliseo (2019)

IDENTIFICATION OF GENOMIC COPY NUMBER VARIATIONS IN LUNG BENIGN METASTASIZING LEIOMYOMATOSIS

Clin Respir J 13(2):105-113
full text

Lung metastasizing leiomyomatosis (LML) is an infrequently diagnosed pathology developed after sexual maturation, commonly preceded by uterine myomas. Symptoms can include difficulties to breathe, cough, dyspnea and pain, because of mechanical obstruction exerted by expanding local growing leiomyomas. Lung leiomyomas are normally detected by imaging studies, but nowadays the precise diagnosis demands histological characterization of biopsies obtained from the affected tissues. The purpose of the present study was to determine the presence of genomic alterations in circulating cells of LML.