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Molina-Hernandez, Anayansi; Rodriguez-Martinez, Griselda; Escobedo-Avila, Itzel; Velasco, Ivan (2013)

HISTAMINE UP-REGULATES FIBROBLAST GROWTH FACTOR RECEPTOR 1 AND INCREASES FOXP2 NEURONS IN CULTURED NEURAL PRECURSORS BY HISTAMINE TYPE 1 RECEPTOR ACTIVATION: CONCEIVABLE ROLE OF HISTAMINE IN NEUROGENESIS DURING CORTICAL DEVELOPMENT IN VIVO

Neural Dev 8():
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During rat development, histamine (HA) is one of the first neuroactive molecules to appear in the brain, reaching its maximal value at embryonic day 14, a period when neurogenesis of deep layers is occurring in the cerebral cortex, suggesting a role of this amine in neuronal specification. We previously reported, using high-density cerebrocortical neural precursor cultures, that micromolar HA enhanced the effect of fibroblast growth factor (FGF)-2 on proliferation, and that HA increased neuronal differentiation, due to HA type 1 receptor (H(1)R) activation.