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Toledo-Ibelles, Paola; Gutierrez-Vidal, Roxana; Calixto-Tlacomulco, Sandra; Delgado-Coello, Blanca; Mas-Oliva, Jaime (2021)

HEPATIC ACCUMULATION OF HYPOXANTHINE: A LINK BETWEEN HYPERURICEMIA AND NONALCOHOLIC FATTY LIVER DISEASE

Arch Med Res 52(7):692-702
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An elevated level of plasma uric acid has been widely recognized as a risk factor for non-alcoholic fatty liver disease (NAFLD), where oxidative stress and inflammation play an important role in the pathophysiology of the disease. Although the complete molecular mechanisms involved remain unknown, while under physiological conditions uric acid presents antioxidant properties, hyperuricemia has been linked to oxidative stress, chronic low-grade inflammation, and insulin resistance, basic signs of NAFLD.