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Salceda, R; Pena-Rangel, MT; Riesgo-Escovar, JR; Sanchez-Chavez, G (2008)

GLYCINE TRANSPORTERS (GLYCINE TRANSPORTER 1 AND GLYCINE TRANSPORTER 2) ARE EXPRESSED IN RETINA

NEUROREPORT 19(13):1295-1299
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The amino acid glycine is an inhibitory neurotransmitter in the spinal cord, brain stem, and vertebrate retina. The effective synaptic concentrations of glycine are regulated by at least two transporters: glycine transporter 1 and glycine transporter 2. Here, we show retinal expression of glycine transporter 1 by in-situ hybridization and of glycine transporter 2 by reverse transcriptase-PCR and in-situ hybridization. In-situ hybridization signals were observed in the ganglionar and inner nuclear layer as well as in the outer nuclear layer of the frog and rat retinas. In addition, accumulation of 3 H-glycine was observed in isolated photoreceptor cells. The expression of these transporters in nonglycinergic cells suggests that they may also modulate electrical signals. NeuroReport 19:1295-1299 (c) 2008 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.