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Bahena-Alvarez, Daniel; Millan-Aldaco, Diana; Rincon-Heredia, Ruth; Escamilla-Avila, Nancy; Hernandez-Cruz, Arturo (2022)

EXPRESSION OF VOLTAGE-GATED CA2+ CHANNELS, INSP(3)RS, AND RYRS IN THE IMMATURE MOUSE OVARY

J Ovarian Res 15(1):
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The postnatal mammalian ovary undergoes a series of changes to ensure the maturation of sufficient follicles to support ovulation and fecundation over the reproductive life. It is well known that intracellular [Ca] signals are necessary for ovulation, fertilization, and egg activation. However, we lack detailed knowledge of the molecular identity, cellular distribution, and functional role of Ca channels expressed during folliculogenesis. In the neonatal period, ovarian maturation is controlled by protein growth factors released from the oocyte and granulosa cells. Conversely, during the early infantile period, maturation becomes gonadotropin-dependent and is controlled by granulosa and theca cells. The significance of intracellular Ca signaling in folliculogenesis is supported by the observation that mice lacking the expression of Ca/calmodulin-dependent kinase IV in granulosa cells suffer abnormal follicular development and impaired fertility.