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Chen, Yong; Wang, Zi-Long; Yeo, Michele; Zhang, Qiao-Juan; Lopez-Romero, Ana E; Ding, Hui-Ping; Zhang, Xin; Zeng, Qian; Morales-Lazaro, Sara L; Moore, Carlene; Jin, Ying-Ai; Yang, Huang-He; Morstein, Johannes; Bortsov, Andrey; Krawczyk, Marcin; Lammert, Frank; Abdelmalek, Manal; Diehl, Anna Mae; Milkiewicz, Piotr; Kremer, Andreas E; Zhang, Jennifer Y; Nackley, Andrea; Reeves, Tony E; Ko, Mei-Chuan; Ji, Ru-Rong; Rosenbaum, Tamara; Liedtke, Wolfgang (2021)

EPITHELIA-SENSORY NEURON CROSS TALK UNDERLIES CHOLESTATIC ITCH INDUCED BY LYSOPHOSPHATIDYLCHOLINE

Gastroenterology 161(1):301-+
full text

Limited understanding of pruritus mechanisms in cholestatic liver diseases hinders development of antipruritic treatments. Previous studies implicated lysophosphatidic acid (LPA) as a potential mediator of cholestatic pruritus.