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Murillo-Rodriguez, Eric; Palomero-Rivero, Marcela; Millan-Aldaco, Diana; Mechoulam, Raphael; Drucker-Colin, Rene (2011)

EFFECTS ON SLEEP AND DOPAMINE LEVELS OF MICRODIALYSIS PERFUSION OF CANNABIDIOL INTO THE LATERAL HYPOTHALAMUS OF RATS

Life Sci. 88(11-12):504-511
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The major non-psychoactive component of Cannabis sativa, cannabidiol (CBD), displays a plethora of actions including wakefulness. In the present study, we addressed whether perfusing CBD via microdialysis into lateral hypothalamus (LH) during the lights-on period would modify the sleep-wake cycle of rats as well as the contents of dopamine (DA) collected from nucleus accumbens (AcbC). Additionally, we tested whether perfusion of CBD into LH would block the sleep rebound after a sleep deprivation period.