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Hernandez-Damian, Jacqueline; Tecalco-Cruz, Angeles C; Rios-Lopez, Diana G; Vazquez-Victorio, Genaro; Vazquez-Macias, Aleida; Caligaris, Cassandre; Sosa-Garrocho, Marcela; Flores-Perez, Blas; Romero-Avila, Margarita; Macias-Silva, Marina (2013)

DOWNREGULATION OF SNON ONCOPROTEIN INDUCED BY ANTIBIOTICS ANISOMYCIN AND PUROMYCIN POSITIVELY REGULATES TRANSFORMING GROWTH FACTOR-BETA SIGNALS

Biochim. Biophys. Acta 1830(11):5049-5058
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SnoN and Ski proteins function as Smad transcriptional corepressors and are implicated in the regulation of diverse cellular processes such as proliferation, differentiation and transformation. Transforming growth factor-β (TGF-β) signaling causes SnoN and Ski protein degradation via proteasome with the participation of phosphorylated R-Smad proteins. Intriguingly, the antibiotics anisomycin (ANS) and puromycin (PURO) are also able to downregulate Ski and SnoN proteins via proteasome.