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David Ochoa-de la Paz, Lenin; Gonzalez-Andrade, Martin; Pasantes-Morales, Herminia; Franco, Rodrigo; Zamora-Alvarado, Ruben; Zenteno, Edgar; Quiroz-Mercado, Hugo; Gonzales-Salinas, Roberto; Gulias-Canizo, Rosario (2018)

DIFFERENTIAL MODULATION OF HUMAN CROSSMARK GABA(C)-RHO 1 RECEPTOR BY SULFUR-CONTAINING COMPOUNDS STRUCTURALLY RELATED TO TAURINE

BMC Neurosci 19():
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The amino acid taurine (2-Aminoethanesulfonic acid) modulates inhibitory neurotransmitter receptors. This study aimed to determine if the dual action of taurine on GABA-ρ1R relates to its structure. To address this, we tested the ability of the structurally related compounds homotaurine, hypotaurine, and isethionic acid to modulate GABA-ρ1R.