QR Code
Hernández-Pérez O; Crespo-Ramírez M; Cuza-Ferrer Y; Anias-Calderón J; Zhang L; Roldan-Roldan G; Aguilar-Roblero R; Borroto-Escuela D; Fuxe K; Perez de la Mora M (2018)

DIFFERENTIAL ACTIVATION OF ARGININE-VASOPRESSIN RECEPTOR SUBTYPES IN THE AMYGDALOID MODULATION OF ANXIETY IN THE RAT BY ARGININE-VASOPRESSIN

PSYCHOPHARMACOLOGY ():1-13
full text

© 2018 Springer-Verlag GmbH Germany, part of Springer Nature Rationale: The amygdala plays a paramount role in the modulation of anxiety and numerous studies have shown that arginine vasopressin (AVP) elicits anxiogenic effects following either its systemic or septal administration. Objectives: The aim of this paper was to study the involvement of vasopressinergic neurotransmission in the amygdaloid modulation of unconditioned anxiety and to ascertain whether or not AVP receptor subtypes may have a differential role in this modulation. Methods: Anxiety behavior was evaluated both in Shock-Probe Burying Test and Light-Dark Box following the bilateral microinfusion of AVP alone or AVP together with either AVP 1a or AVP 1b receptor antagonists into the central amygdala (CeA). Results: AVP microinfusion elicited at low (1 ng/side) but not at high doses (10 ng/side) anxiogenic-like responses in the Shock-Probe Burying Test but not in the Light-Dark Box. SSR149415, an AVP 1b antagonist unlike Manning compound, an AVP 1a antagonist, fully prevented AVP effects in the Shock-Probe Burying Test when it was administered simultaneously with AVP. In addition, oxytocin receptor blockade also failed to affect AVP effects. No effects of any AVP antagonist by itself were observed in both anxiety paradigms. Conclusions: Our results indicate that AVP 1b receptor contribute to the amygdaloid modulation of anxiety at least in the context of the Shock-Probe Burying Test since no effects were noticed in the Light-Dark Box. It remains to the future to ascertain whether AVP receptor subtypes have indeed differential actions either in the modulation of global or specific features of unconditioned anxiety.