QR Code
Gao, Yan; Nish, Simone A; Jiang, Ruoyi; Hou, Lin; Licona-Limon, Paula; Weinstein, Jason S; Zhao, Hongyu; Medzhitov, Ruslan (2013)

CONTROL OF T HELPER 2 RESPONSES BY TRANSCRIPTION FACTOR IRF4-DEPENDENT DENDRITIC CELLS

Immunity 39(4):722-732
full text

CD4⁺ T cell differentiation is regulated by specialized antigen-presenting cells. Dendritic cells (DCs) produce cytokines that promote naive CD4⁺ T cell differentiation into T helper 1 (Th1), Th17, and inducible T regulatory (iTreg) cells. However, the initiation of Th2 cell responses remains poorly understood, although it is likely that more than one mechanism might be involved. Here we have defined a specific DC subset that is involved in Th2 cell differentiation in vivo in response to a protease allergen, as well as infection with Nippostrongylus brasiliensis. We have demonstrated that this subset is controlled by the transcription factor interferon regulatory factor 4 (IRF4), which is required for their differentiation and Th2 cell-inducing function. IRF4 is known to control Th2 cell differentiation and Th2 cell-associated suppressing function in Treg cells. Our finding suggests that IRF4 also plays a role in DCs where it controls the initiation of Th2 cell responses.