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Hernandez-Ramirez, Susana; Osorio-Gomez, Daniel; Escobar, Martha L; Rodriguez-Duran, Luis; Velasco, Myrian; Bermudez-Rattoni, Federico; Hiriart, Marcia; Guzman-Ramos, Kioko R (2021)

CATECHOLAMINERGIC STIMULATION RESTORES HIGH-SUCROSE DIET-INDUCED HIPPOCAMPAL DYSFUNCTION

Psychoneuroendocrinology 127():
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Increasing evidence suggests that long-term consumption of high-caloric diets increases the risk of developing cognitive dysfunctions. In the present study, we assessed the catecholaminergic activity in the hippocampus as a modulatory mechanism that is altered in rats exposed to six months of a high-sucrose diet (HSD). Male Wistar rats fed with this diet developed a metabolic disorder and showed impaired spatial memory in both water maze and object location memory (OLM) tasks. Intrahippocampal free-movement microdialysis showed a diminished dopaminergic and noradrenergic response to object exploration during OLM acquisition compared to rats fed with normal diet. In addition, electrophysiological results revealed an impaired long-term potentiation (LTP) of the perforant to dentate gyrus pathway in rats exposed to a HSD. Local administration of nomifensine, a catecholaminergic reuptake inhibitor, prior to OLM acquisition or LTP induction, improved long-term memory and electrophysiological responses, respectively. These results suggest that chronic exposure to HSD induces a hippocampal deterioration which impacts on cognitive and neural plasticity events negatively; these impairments can be ameliorated by increasing or restituting the affected catecholaminergic activity.