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Hansberg, W; Jimenez-Estrada, M; Chilpa, RR; Apan, TR; Lledias, F; Arrieta, D; Aguilar, FJA (2006)

ANTI-INFLAMMATORY ACTIVITY OF CACALOL AND CACALONE SESQUITERPENES ISOLATED FROM PSACALIUM DECOMPOSITUM

J ETHNOPHARMACOL 105():34-38
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The hexane extract and two sesquiterpenic compounds, cacalol and cacalone, were isolated from the roots and rhizomes of Psacalium decompositum. Then, their anti-inflammatory activity was evaluated in carrageenan-induced rat paw edema and 12-0-tetradecanoylphorbol-13-acetate (TPA)-induced ear edema. Indomethacin was used as the anti-inflammatory agent of reference.In the rat paw model of inflammation, both the hexane extract and the sesquiterpenes isolated from Psacalium decompositum showed a clear dose-dependent inhibition of the carrageenan-induced edema (P < 0.05), with important differences among them during the temporal course of the inhibition. In the TPA-induced mouse ear edema all tested compounds showed anti-inflammatory activity in dose-dependent manner (P < 0.05). In both models, cacalone showed the most prominent anti-inflammatory activity.We conclude that some of the beneficial effects attributed to Psacalium decompositum in traditional medicine can be related with the anti-inflammatory activity of cacalol and cacalone. (c) 2005 Elsevier Ireland Ltd. All rights reserved.