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| Germ cell function and maintenance |
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| Germ cells carry information for the next generations. All the necessary elements to preserve the germline, and to undergo embryogenesis are accumulated in the oocyte cytoplasm. Germ cell cytoplasm contains germ granules known as P granules, which are made of mRNA/protein complexes. We are interested in studying P granule components and their function. The RNA helicase VBH-1 is a P granule component that is essential for germline function. Some vbh-1(RNAi) animals die during embryogenesis and others developed into sterile adults. We are using a combination of Microarray and RNAi analysis to understand VBH-1 function. We are also using the Two Hybrid technique and inmunoprecipitation analysis to isolate proteins that interact with VBH-1, which will help us to elucidate its function.
Technician: Silvia Salinas.
Graduate student: Daniel Paz Gómez. |
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