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Bermudez-Rattoni, F; Rodriguez-Ortiz, CJ; De la Cruz, V; Gutierrez, R (2005)

PROTEIN SYNTHESIS UNDERLIES POST-RETRIEVAL MEMORY CONSOLIDATION TO A RESTRICTED DEGREE ONLY WHEN UPDATED INFORMATION IS OBTAINED

LEARN MEMORY 12(5):533-537
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Consolidation theory proposes that through the synthesis of new proteins recently acquired memories are strengthened over time into a stable long-term memory trace. However, evidence has accumulated suggesting that retrieved memory is susceptible to disruption, seeming to consolidate again (reconsolidate) to be retained in long-term storage. Here we show that intracortical blockade of protein synthesis in the gustatory cortex after retrieval of taste-recognition memory disrupts previously consolidated memory to a restricted degree only if the experience is updated. Our results suggest that retrieved memory can be modified as part of a mechanism for incorporating updated information into previously consolidated memory.