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Georgellis, D; SOHLBERG, B; HARTL, FU; VONGABAIN, A (1995)

IDENTIFICATION OF GROEL AS A CONSTITUENT OF AN MESSENGER-RNA-PROTECTION COMPLEX IN ESCHERICHIA-COLI

MOL MICROBIOL 16(6):1259-1268
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An RNA-binding activity has been identified in Escherichia coli that provides physical protection of RNA against ribonucleases in an ATP- and Mg2+-dependent manner. This binding activity is stimulated under growth conditions known to cause a decrease in the rate of mRNA decay. RNA protection is mediated by a protein complex that contains a modified form of the chaperonin GroEL as an indispensable constituent. These results suggest a new role for GroEL as an RNA chaperone.