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Hernandez-Cruz, A; Hernandez-Guijo, JM; Albinana, E; Segura-Chama, P; Hernandez, A (2010)

DOWN-MODULATION OF CA2+ CHANNELS BY ENDOGENOUSLY RELEASED ATP AND OPIOIDS: FROM THE ISOLATED CHROMAFFIN CELL TO THE SLICE OF ADRENAL MEDULLAE

CELL MOL NEUROBIOL 30(8):1209-1216
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Modifications in Ca2+ influx may lead to profound changes in the cell activity associated with Ca2+ dependent processes, from muscle contraction and neurotransmitter release to calcium-mediated cell death. Therefore, calcium entry into the cell requires fine regulation. In this context, understanding of the modulation of voltage-dependent Ca2+ channels seems to be critical. The modulatory process results in the enhancement or decrement of calcium influx that may regulate the local and global cytosolic Ca2+ concentrations. Here, we summarize the well-established data on this matter described in isolated chromaffin cells by our laboratory and others, and the new results we have obtained in a more physiological preparation: freshly isolated slices of mouse adrenal medullae.