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Bargas, J; Galarraga, E; Rueda-Orozco, PE; Mendoza, E; Hernandez, R; Aceves, JJ; Ibanez-Sandoval, O (2009)

DIVERSITY IN LONG-TERM SYNAPTIC PLASTICITY AT INHIBITORY SYNAPSES OF STRIATAL SPINY NEURONS

LEARN MEMORY 16(8):474-478
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Procedural memories and habits are posited to be stored in the basal ganglia, whose intrinsic circuitries possess important inhibitory connections arising from striatal spiny neurons. However, no information about long-term plasticity at these synapses is available. Therefore, this work describes a novel postsynaptically dependent long-term potentiation (LTP) at synapses among spiny neurons (intrinsic striatal circuitry); a postsynaptically dependent long-term depression (LTD) at synapses between spiny and pallidal neurons (indirect pathway); and a presynaptically dependent LTP at strionigral synapses (direct pathway). Interestingly, long-term synaptic plasticity differs at these synapses. The functional consequences of these long-term plasticity variations during learning of procedural memories are discussed.