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Lopez-Casillas, F; Hernandez, M; Cabrera-Ponce, JL; Fragoso, G; Guevara-Garcia, A; Rosas, G; Leon-Ramirez, C; Juarez, P; Sanchez-Garcia, G; Cervantes, J; Acero, G; Toledo, A; Cruz, C; Bojalil, R; Herrera-Estrella, L; Sciutto, E (2007)

A NEW HIGHLY EFFECTIVE ANTICYSTICERCOSIS VACCINE EXPRESSED IN TRANSGENIC PAPAYA

VACCINE 25(21):4252-4260
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The use of transgenic plants as new anti gen-delivery systems for subunit vaccines has been increasingly explored. We herein report progress toward a papaya-based vaccine against cysticercosis. Synthetic peptides (KETc 1, KETc 12, KETc7) were successfully expressed in 19 different transgenic papaya clones and found to be immunogenic. Complete protection against cysticercosis was induced with the soluble extract of the clones that expressed the higher levels of transcripts in up to 90% of the immunized mice. This study represents a key step towards the development of a more effective, sustainable and affordable oral subunit vaccine against human and pig cysticercosis. (c) 2007 Elsevier Ltd. All rights reserved.